NR4A2 _HNSC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004021
Fusion event
HPV-NR4A2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E5
Start
5227
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
157182211/156325699 (Hg38)
End
157182211/156325699 (Hg38)
Location type
Exon8
Target gene
NR4A2
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-335-5p ; hsa-mir-133a-3p ; hsa-mir-520f-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-3675-3p ; hsa-mir-3617-3p ; hsa-mir-34a-3p ; hsa-mir-548c-3p ; hsa-mir-129-5p ; hsa-mir-206 ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-128-1/Upstream/4957288; hsa-mir-10b/Downstream/2861136;
Nearest TSS
ENST00000437798/Upstream/5444; ENST00000416888/Downstream/4422;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/4865, chr2-CpG: 19/Downstream/2178
Upstream sequence
gaggaggaagtcgggaagagggaaggcgggggcgcggccCGCCCGGCGCTCGAGTTACACCCGCCCAGCCCGCCTCGAGTGACAGCCCCGCGCGCCTCGC
Downstream sequence
TTCCATTATCATTCCAGTTCCTTTGAAGTGCTTGGGAGGAGGTCTTAGAAAGGTAAAGTGTCCAGGAAAAGTTTGTCAATTATTGCTGGCGGTGGCACCA
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate