Basic Information
VIS ID
TVIS20004025
Fusion event
HPV-chr11:p15.1 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E6
Start
130
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17036961/17015414 (Hg38)
End
17036961/17015414 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
LOC107984416 ; LOC112268085
Nearest miRNA
hsa-mir-210/Upstream/1045793; hsa-let-7a-2/Downstream/1372373;
Nearest TSS
ENST00000527297/Upstream/971; ENST00000620945/Downstream/60198;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/557, chr11-CpG: 56/Downstream/61878
Nearby gene
OR7E14P(-36471) ;
Upstream sequence
GAGAGGGCTCCAGGTTATCCGGGCTCTGCTTCTGCCGCCGCCGTCGGGGCTGGACCCCCTTACCAGGGGGTCTGGGCAGCCCACTCTGTAGCTGCCGCAC
Downstream sequence
CATCTCGTGGTCCCTGTGGTCCAGCACGCGGGGCAGGAACAGGGAGGACTTCTGTGTGCGGCGGGTCTTGAAGCCCCTGCGGGGCCGGCCCTTGCCGTTC
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate