PBX1 _HNSC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004033
Fusion event
HPV-PBX1 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E7
Start
1828
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
164533065/164563828 (Hg38)
End
164533065/164563828 (Hg38)
Location type
Intron2
Target gene
PBX1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-149-5p ; hsa-mir-196b-5p ; hsa-mir-198 ; hsa-mir-1247-3p ; hsa-mir-3074-5p ; hsa-mir-4722-3p ; hsa-mir-617 ; hsa-mir-6505-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6882-3p
Nearest miRNA
hsa-mir-101-1/Upstream/2221188; hsa-mir-1182/Downstream/1344093;
Nearest TSS
ENST00000473358/Upstream/1023; ENST00000474046/Downstream/12956;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/242298, chr1-CpG: 45/Downstream/12475
Nearest cancer related gene
PBX1(OG, No orient, 0)
Upstream sequence
gagtctccctcttgtcacccaggatgaagtgcaatggcgcgatctcagctcaccacaacctccgcctcccaggttcaagcgattctctgcctcagcctac
Downstream sequence
cgagtagctgggattacaggcatgcgccaccacgcccggctaattttgtgtttttagtagagacagggtttctccatgttggtcaggctggtcttgaact
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate