PLCXD2 _HNSC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004046
Fusion event
HPV-PLCXD2 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV33
Reference genome
Not given
Gene
E6
Start
855
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
111416149/111697302 (Hg38)
End
111416149/111697302 (Hg38)
Location type
Intron1
Target gene
PLCXD2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-1273e ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-503-3p ; hsa-mir-6861-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-4291 ; hsa-mir-193a-5p ; hsa-mir-205-5p ; hsa-mir-7157-5p ; hsa-mir-4310
Nearest miRNA
hsa-let-7g/Upstream/2094405; hsa-mir-12124/Downstream/415499;
Nearest TSS
ENST00000440867/Upstream/5954; ENST00000474484/Downstream/35159;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22605, chr3-CpG: 59/Downstream/162088
Upstream sequence
TGGAGTGCGTGGGGGACCGGCTGTTGGCGGGTGAGGCTTGGCTTGAGGCACGCCTGGTGGAAAGGGGGAAAGAAACAGCGCCTCCCAGGGGCGGTGCCAC
Downstream sequence
TACCACATTATTGAGTGAGAATGTCTTCTAAGAAAGCAAAAAGCCTCTGAATAAAACAAGCACACTCGAGAGGCCTAAAAAGAAAAATTGGGTGATAAAG
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate