Basic Information
VIS ID
TVIS20004073
Fusion event
HPV-chr11:p13 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E7
Start
897
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
32000137/31978591 (Hg38)
End
32000137/31978591 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11E
Nearest miRNA
hsa-mir-210/Upstream/3501043; hsa-let-7a-2/Downstream/2963246;
Nearest TSS
ENST00000527297/Upstream/160529; ENST00000532721/Downstream/62657;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/151309, chr11-CpG: 39/Downstream/8665
Nearby gene
RCN1(-112339) ;
Upstream sequence
ctgagccctctgcaaagaaaatccttcccctccttccctcgctatttcattacttgtttacatttaattgatatttgtgtttgtcttgtttgttgtatat
Downstream sequence
tagttccaacatgtcagctggatgagagaaggggctttgatctacctcatacactgcctggtctccaatgcctggaacagcacctgactcatgtatgcat
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate