ZBTB7C _HNSC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004147
Fusion event
HPV-ZBTB7C integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E7
Start
821
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45567136/48040765 (Hg38)
End
45567136/48040765 (Hg38)
Location type
Exon2
Target gene
ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/660200; hsa-mir-122/Downstream/629835;
Nearest TSS
ENST00000575820/Upstream/109619; ENST00000591412/Downstream/96596;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/10923, chr18-CpG: 116/Downstream/95178
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
attatgacattttatgggcaaggcaatgttgtaaacatttgcatgtatttgcatgtattgagtcagatttcttattacccttagttttctgggatgaggt
Downstream sequence
CAGCATCCTGGCTGCGTTGAGGATGTGCTTGACATTGCCAGCGGTGATGGTGAGCGTGGAGGTGTAGGCGAACTCCAGGATAGCAGCCAGAGCCTCAGGC
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate