ZBTB7C _HNSC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004148
Fusion event
HPV-ZBTB7C integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Tumor
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
28928286
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Not given
Gene
E6
Start
549
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45567241/48040870 (Hg38)
End
45567241/48040870 (Hg38)
Location type
Exon2
Target gene
ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/660305; hsa-mir-122/Downstream/629730;
Nearest TSS
ENST00000575820/Upstream/109724; ENST00000591412/Downstream/96491;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/11028, chr18-CpG: 116/Downstream/95073
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
catcttcgtcgtcgtcatcgtcctccttgtcatcctcctcccccccgtcccccCCAGGCTCCATGATCTCCAGGCACACGTTCACGATGCACTGGATCTC
Downstream sequence
AAAGTCGATCTCATAGACGTAGGGCTGGCTGGCTAGGGTGCCGGCTGTGAAAAGCTTCTTGAAGTACTTGCTGCAGGCAGCCAGGACGGAGCGGTGGGTC
Reference
Koneva, L. A., et al. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. Mol Cancer Res ,2018,16(1): 90-102.
Curate