Basic Information
VIS ID
TVIS20004149
Fusion event
HPV-chr2 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
+
Gene
E2
Start
2827
End
3062
Orient
+
Integrated sequence
GACCTACGTGACCATATAGACTATTGGAAACACATGCGCCTAGAATGTGCTATTTATTACAAGGCCAGAGAAATGGGATTTAAACATATTAACCACCAGGTGGTGCCAACACTGGCTGTATCAAAGAATAAAGCATTACAAGCAATTGAACTGCAACTAACGTTAGAAACAATATATAACTCACAATATAGTAATGAAAAGTGGACATTACAAGACGTTAGCCTTGAAGTGTATTT
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
28595279/28372412 (Hg38)
End
28595577/28372710 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-1301/Upstream/375963; hsa-mir-10b/Downstream/4159443;
Nearest TSS
ENST00000437798/Upstream/61953; ENST00000460736/Downstream/19738;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/481515, chr2-CpG: 302/Downstream/17387
Nearby gene
LOC105374382(-6646) ; LOC105374383(+4946) ;
Upstream sequence
atgaaatagggataacagtggtacttcctgcacaggtttattaaaaagcagtgaagcctgggagagttcctggaacataggaagctttcaaaaagtgtta
Downstream sequence
gattgattaaggtcagagtcatcaaacgatgctaaggctggtgggcgagatttgatgaggaacaggctttatagtcttggcatctcctcaccacatacct
Target sequence
gtgtcagaaagtaaggaagtgctcaaagaacaacgcggacatgtcaaaatgacacaggagtctgcctgaaggggctcctactgactaaaactgagagaatttgagcatcaaaagaaataattacagtaacggatcacaacgctttgactacagtggagatccatgggtccagatggatataagtgaatgaatgaataaataaatgagggagaaaggaaaactcttacagtagaatgccagctgataaatgtagag
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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