Basic Information
VIS ID
TVIS20004150
Fusion event
HPV-chr2 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
+
Gene
E1/E2
Start
2505
End
3062
Orient
+
Integrated sequence
GATGTAAAGCATAGACCATTGGTACAACTAAAATGCCCTCCATTATTAATTACATCTAACATTAATGCTGGTACAGATTCTAGGTGGCCTTATTTACATAATAGATTGGTGGTGTTTACATTTCCTAATGAGTTTCCATTTGACGAAAACGGAAATCCAGTGTATGAGCTTAATGATAAGAACTGGAAATCCTTTTTCTCAAGGACGTGGTCCAGATTAAGTTTGCACGAGGACGAGGACAAGGAAAACGATGGA
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
28595311/28372444 (Hg38)
End
28595730/28372863 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-1301/Upstream/375995; hsa-mir-10b/Downstream/4159290;
Nearest TSS
ENST00000437798/Upstream/61985; ENST00000460736/Downstream/19585;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/481547, chr2-CpG: 302/Downstream/17234
Nearby gene
LOC105374382(-6678) ; LOC105374383(+4914) ;
Upstream sequence
GCTGGGTTTTGGTGAACCTGTTGTAGCGtgtgtaggttataaaaaatttcagaattccaatttcttcataaaataaagataatgtaactttacttacagg
Downstream sequence
ccaacctgacctggtgtcaaggttaacatcactaatggtgggacaggtcagaatcataagcccaatgtgtaatgccccgaggagaacatggcatctcttc
Target sequence
acgcggacatgtcaaaatgacacaggagtctgcctgaaggggctcctactgactaaaactgagagaatttgagcatcaaaagaaataattacagtaacggatcacaacgctttgactacagtggagatccatgggtccagatggatataagtgaatgaatgaataaataaatgagggagaaaggaaaactcttacagtagaatgccagctgataaatgtagagtgagtgacagaaatagtcactgtttggcaacc
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
Curate