Basic Information
VIS ID
TVIS20004151
Fusion event
HPV-chr2 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
+
Gene
E1
Start
2173
End
2575
Orient
+
Integrated sequence
GTGATTGGAAGCAAATTGTTATGTTTTTAAGGTATCAAGGTGTAGAGTTTATGTCATTTTTAACTGCATTAAAAAGATTTTTGCAAGGCATACCTAAAAAAAATTGCATATTACTATATGGTGCAGCTAACACAGGTAAATCATTATTTGGTATGAGTTTAATGAAATTTCTGCAAGGGTCTGTAATATGTTTTGTAAATTCTAAAAGCCATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTATGTTAG
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
28595585/28372718 (Hg38)
End
28595729/28372862 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/376269; hsa-mir-10b/Downstream/4159291;
Nearest TSS
ENST00000437798/Upstream/62259; ENST00000460736/Downstream/19586;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/481821, chr2-CpG: 302/Downstream/17235
Nearby gene
FLJ31356(-11546) ; FOSL2(+20049) ;
Upstream sequence
GAGGTAGGATATGAACATTTGAAATAGACCTAGCCTTGTCAGGCATAATAAGAAAGATATAACATCAGAGTTTAAAAAAAAATAGCTGAACTTTTGGTTG
Downstream sequence
accaacctgacctggtgtcaaggttaacatcactaatggtgggacaggtcagaatcataagcccaatgtgtaatgccccgaggagaacatggcatctctt
Target sequence
aaggtcagagtcatcaaacgatgctaaggctggtgggcgagatttgatgaggaacaggctttatagtcttggcatctcctcaccacatacctatcaaatgcaaagggaaagacggtgagtttatggtggagaaatctttcaggc
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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