Basic Information
VIS ID
TVIS20004153
Fusion event
HPV-chr2 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
E2/E5
Start
3693
End
4038
Orient
-
Integrated sequence
TGCAGTGTCGTCTACATGGCATTGGACAGGACATAATGTAAAACATAAAAGTGCAATTGTTACACTTACATATGATAGTGAATGGCAACGTGACCAATTTTTGTCTCAAGTTAAAATACCAAAAACTATTACAGTGTCTACTGGATTTATGTCTATATGACAAATCTTGATACTGCATCCACAACATTACTGGCGTGCTTTTTGCTTTGCTTTTGTGTGCTTTTGTGTGTCTGCCTATTAATACGTCCGCTGCTT
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
28595741/28372874 (Hg38)
End
28595968/28373101 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/376425; hsa-mir-10b/Downstream/4159052;
Nearest TSS
ENST00000437798/Upstream/62415; ENST00000460736/Downstream/19347;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/481977, chr2-CpG: 302/Downstream/16996
Nearby gene
FLJ31356(-11307) ; FOSL2(+19810) ;
Upstream sequence
GTGTAATCAAACTGCCTTAGAAAGGAGGGTGAACAAAGGGAGGGCAGGTCTAGGAAGATTTGGAACCCAAAGCCCTCTTGTCTTAAAGTGTGTTGTTACC
Downstream sequence
tgtttcctattcaaggaaactaatgaggcatgacaactcaacgcagctcagaaccctgacttggaacctggaccagaaaggcaaatgaggcatcattggg
Target sequence
tggtgtcaaggttaacatcactaatggtgggacaggtcagaatcataagcccaatgtgtaatgccccgaggagaacatggcatctcttctgtggcatccttgccaagaatgcccagccccagagtggcaactgacagactcatttggggggccatattctaccaaataaatggcccaaacttttgaagactgtcaaggtcacaaaagacaaggagagattgaagatc
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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