Basic Information
VIS ID
TVIS20004160
Fusion event
HPV-chr7 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
E2
Start
2905
End
3288
Orient
-
Integrated sequence
TTTAAACATATTAACCACCAGGTGGTGCCAACACTGGCTGTATCAAAGAATAAAGCATTACAAGCAATTGAACTGCAACTAACGTTAGAAACAATATATAACTCACAATATAGTAATGAAAAGTGGACATTACAAGACGTTAGCCTTGAAGTGTATTTAACTGCACCAACAGGATGTATAAAAAAACATGGATATACAGTGGAAGTGCAGTTTGATGGAGACATATGCAATACAATGCATTATACAAACTGGACA
Host Sequence
Chromosome
chr7
Reference genome
GRCh37/hg19
Start
124000000
End
124000000
Orient
+
Location type
Intergenic
Nearest CpG islands
None/Target, None/Upstream, None/Downstream
Nearby gene
SPAM1(-114539) ; TMEM229A(+52477) ;
Upstream sequence
aaggttaaggactttgagatgagagtatcatctcagattatgcagatgagctcaacctaatcacatgagtccttaaaagaaacttttccagatgaggtca
Downstream sequence
TTACAATTCTTCCTAAGTAATCATATATATATTTTTGTACACTTTTTTTGTTATATTTGCATTTACCAGTAATTTTCCTCAATGATATTTTTCTGTTTTG
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
Curate