Basic Information
VIS ID
TVIS20004164
Fusion event
HPV-chr20 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
L2
Start
4173
End
4408
Orient
-
Integrated sequence
TTCATATATATTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAG
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
52118023/53501484 (Hg38)
End
52118075/53501536 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/2048507; hsa-mir-1-1/Downstream/566872;
Nearest TSS
ENST00000382410/Upstream/12528; ENST00000424252/Downstream/2778;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/528003, chr20-CpG: 26/Downstream/79983
Nearby gene
TSHZ2(-6154) ; LOC101927770(+51233) ;
Upstream sequence
ccagagcttttagaagcggggcacactgctctttcaaaggaggagggaggcagagggctgatggatcagtgaattttcagctgacaacacgccttaagac
Downstream sequence
atatatatatatatatatataatatgtgtgtttgtatatatgtatacatatatgtagatatatatatgtgtatatatatgtatatatacccatacatata
Target sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaatatatatat
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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