Basic Information
VIS ID
TVIS20004166
Fusion event
HPV-chr1 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
L2
Start
4177
End
4633
Orient
-
Integrated sequence
TATATATTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGTACA
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
199440186/199471058 (Hg38)
End
199440241/199471113 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/611905; hsa-mir-1182/Downstream/2248395;
Nearest TSS
ENST00000473358/Upstream/322460; ENST00000447034/Downstream/556489;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1311824, chr1-CpG: 36/Downstream/564233
Nearby gene
LINC01222(+452093) ;
Upstream sequence
gaaactatgccgtaaaacagatgtgctgtcatctagtcttttttgtttcacttatagaacacagtagatttagcataattctcaagggccctgggatttt
Downstream sequence
tgggtctcagttcccagcatgaattttggaggaaaacaaaaattcaaaccaaagcaAGAATTCATTTTTGCTATGTTGAATTTAAGTCAATTGTAAGTTG
Target sequence
aaaaaaaaataaataaataaataaataaaaaaaaaaaaaaaaaaaaaaaaaatat
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
Curate