Basic Information
VIS ID
TVIS20004191
Fusion event
HPV-chr12 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
L2
Start
4187
End
4722
Orient
-
Integrated sequence
TTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGTACAGGCGGACGCA
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
66451369/66057589 (Hg38)
End
66451445/66057665 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/33863; hsa-mir-1178/Downstream/193417;
Nearest TSS
ENST00000382841/Upstream/26523; ENST00000510317/Downstream/73037;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/231188, chr12-CpG: 30/Downstream/73019
Nearby gene
LLPH(-65403) ; MIR6074(+33863) ;
Upstream sequence
AAACAGTGTAGTAGAACAGACAGCATATCTAAATGAGAGTTGAGTGATCACATGTATTAATACTTCTTCCTTAGTAGCAGTGAAATAGCTAACATGGATA
Downstream sequence
tttttttttttttttttgagacggagtctcactctgttgcccagactggagtacaatgctacaatcttggctcactgcaacctctgcctcccaggtgcaa
Target sequence
GAAttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttt
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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