VISDB Viral Integration Site DataBase

VIS ID

TVIS20004192

Fusion event

HPV-PAWR integration

Validated

Yes

Detection method

APOT and sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Good

Reported year

2018

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Strand

-

Gene

L2

Start

4177

End

4618

Orient

-

Integrated sequence

TATATATTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGTACA

Chromosome

chr12

Cytoband

q21.2

Reference genome

Start

End

80007807/79614027 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-8084 ; hsa-mir-621 ; hsa-mir-3692-3p ; hsa-mir-1179 ; hsa-mir-5047 ; hsa-mir-218-5p ; hsa-mir-7156-3p ; hsa-mir-1301-3p ; hsa-mir-367-3p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-101-5p ; hsa-mir-591 ; hsa-mir-6512-5p ; hsa-mir-6869-5p ; hsa-mir-496 ; hsa-mir-4461 ; hsa-mir-590-3p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3611 ; hsa-mir-4282 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-493-3p ; hsa-mir-4680-5p ; hsa-mir-186-3p ; hsa-mir-4733-5p ; hsa-mir-3607-5p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-548l ; hsa-mir-548n ; hsa-mir-653-5p ; hsa-mir-1267 ; hsa-mir-124-5p ; hsa-mir-488-5p ; hsa-mir-95-5p ; hsa-mir-4307 ; hsa-mir-5586-5p ; hsa-mir-8066 ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p

Nearest miRNA

hsa-let-7i/Upstream/194652; hsa-mir-1178/Downstream/1218506;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/809353, chr12-CpG: 198/Downstream/75724

Nearby gene

MIR5692B(-155313) ;

Nearest cancer related gene

PAWR(TSG, No orient, 0)

Upstream sequence

TATTTAGCAGGTTTTTTAATAGAGTCTGAGAATGAGCTTCTTGCAACTTTCACATTATCATATTACAACATTCACCACTGATTATCTGTACTCAAGGTCA

Downstream sequence

gagaaggagtttcactcttgttgcccaggctacagtgcaatggtgtcatctgggctcaccgcaacctctgcctcccgggttcaagtgattctcctgcctc

Target sequence

tatatatttttttttttttttttttttttttttttttttttttttttttttttt