Basic Information
VIS ID
TVIS20004193
Fusion event
HPV-chr15 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
L2
Start
4174
End
4444
Orient
-
Integrated sequence
TCATATATATTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGT
Host Sequence
Chromosome
chr15
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
32767594/32475393 (Hg38)
End
32767649/32475448 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1268a/Upstream/1410252; hsa-mir-10393/Downstream/1906621;
Nearest TSS
ENST00000557528/Upstream/19759; ENST00000561999/Downstream/60599;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/40216, chr15-CpG: 109/Downstream/60683
Nearby gene
WHAMMP1(-44399) ; GOLGA8O(+19759) ;
Upstream sequence
gcagccttgcttctccttcctaatttgctctgtactcttaaaaaccaggtcacaaacatatcggaatatagaattgtgtgtaaagtaagagtaagtaggc
Downstream sequence
tatatatatatatatatatatatatatatataAAGGcctcattttgcaggtgaggacactgaagattataggagaaagaagggcttcatgcaaaaccacg
Target sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaatatatata
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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