GNGT2 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004194
Fusion event
HPV-GNGT2 integration
Validated
Yes
Detection method
APOT and sequencing
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Good
Reported year
2018
PubMed ID
29364907
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
AF125673.1
Strand
-
Gene
L1
Start
6645
End
6877
Orient
-
Integrated sequence
CACGCAGTACAAATATGTCATTATGTGCTGCCATATCTACTTCAGAAACTACATATAAAAATACTAACTTTAAGGAGTACCTACGACATGGGGAGGAATATGATTTACAGTTTATTTTTCAACTGTGCAAAATAACCTTAACTGCAGACGTTATGACATACATACATTCTATGAATTCCACTATTTTGGAGGACTGGAATTTTGGTCTACAACCTCCCCCAGGAGGCACACTA
Host Sequence
Chromosome
chr17
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
47285978/49208616 (Hg38)
End
47286154/49208792 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNGT2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10226/Upstream/484141; hsa-mir-1250/Downstream/79554;
Nearest TSS
ENST00000595228/Upstream/75649; ENST00000573347/Downstream/120;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/15544, chr17-CpG: 28/Downstream/10815
Nearby gene
PHOSPHO1(-14577) ; ABI3(+1434) ;
Upstream sequence
agactagctggtgatggaggtagaataagcataaatgtatcaaaaagaggagttgatagatcttaaagaatgattggatttgaagggcaaaggaagagaa
Downstream sequence
CCAGTGATACTAAGAGTAGATCCCAGCCCAGTGCAACCTCAGCCCCTCTCACCTGCCACAGAAGAGCACACTCTCCAAGTCACTTGTCCTGGACTCAGGT
Target sequence
GCCTCAGCCACCTCCCACGGGCACCTGC
Reference
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.
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