VISDB Viral Integration Site DataBase

VIS ID

TVIS20004195

Fusion event

HPV-INSR integration

Validated

Yes

Detection method

APOT and sequencing

Data source

Curated

Sample type

Disease

Cervical carcinoma (CC)

Quality evaluation

Good

Reported year

2018

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Strand

-

Gene

L2

Start

4179

End

4470

Orient

-

Integrated sequence

TATATTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGTACAGG

Chromosome

chr19

Cytoband

p13.2

Reference genome

Start

End

7124609/7124598 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-195-5p ; hsa-mir-7108-3p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-1227/Upstream/387763; hsa-let-7e/Downstream/492841;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/24878, chr19-CpG: 17/Downstream/18298

Nearby gene

ZNF557(-36574) ; MBD3L3(+65907) ;

Upstream sequence

gtaatcccagcactttgggaggctgagacgagcaggtcagaagttcaagaccagcctggccaacatggtgaaacctgtctctactaaaaataccaaaata

Downstream sequence

atatatatatatatatatatatatatatatatatatatatgaaataaaataaaaataaaGGTTTTGGAgtctgtctccgcctgctgttttggaagctcta

Target sequence

aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaatatatatat