Fusion event
HPV-chr20 integration
Detection method
APOT and sequencing
Disease
Cervical carcinoma (CC)
Integrated sequence
ATATATATTTTTTTTTTGTTTGTTTGTTTGTTTTTTAATAAACTGTTATCACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGTGCATCGGCTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGGTTGAAGGCAAAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGTAC
End
52118075/53501536 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/2048507; hsa-mir-1-1/Downstream/566872;
Upstream sequence
GTTCCAGGTGTCTTTGGAATTAATCTCGTGTCAGAAAATTATATGAGATGATGCCTGATGCCTCTTGTCCATAATAGATCTTAGTCCCTCATTTAAGGAT
Downstream sequence
atatatatatatatatatataatatgtgtgtttgtatatatgtatacatatatgtagatatatatatgtgtatatatatgtatatatacccatacatata
Target sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaatatatatat
Warburton, A., et al. HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression. PLoS Genet ,2018,14(1): e1007179.