Fusion event
HPV-SERPINB7 integration
Detection method
WGS, RNA-seq, Whole-Exome sequencing, PCR
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Perfect
Integrated sequence
ATTTTTTTTCAGATGTCTCTTTGGCTGCCTAGTGAGGCCACTGTCTACTTGCCTCCTGTCCCAGTATCTAAGGTTGTAAGCACGGATGAATATGTTGCAC| |GCACAAACATATATTATCATGCAGGAACATCCAGACTACTTGCAGTTGGACATCCCTATTTTCCTATTAAAAAACCTAACAATAACAAAATATTAGTTCC
End
61463507/63796273 (Hg38)
Nearest miRNA
hsa-mir-1-2/Upstream/5345115; hsa-mir-5011/Downstream/3285311;
Junction sequence
CTTATATACTTAGTTGGTGATGATTTGTAAATACGAGAACTATATTCTTCTTTATAGGACTACAT---[AAA]---GCACAAACATATATTATCATGCAGGAACATCCAGACTACTTGCAGTTGGACATCCCTATTTTCC
* Color:
Human Sequence
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Virus Sequence
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Overlapped sequence
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Unknown sequence
Parfenov, M., et al. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A,2014,111(43): 15544-15549.