Fusion event
HPV-chr1:q31.2 integration
Detection method
WGS, RNA-seq, Whole-Exome sequencing, PCR
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Perfect
Integrated sequence
CATATTACTATATGGTGCAGCTAACACAGGTAAATCATTATTTGGTATGAGTTTAATGAAATTTCTGCAAGGGTCTGTAATATGTTTTGTAAATTCTAAA| |AGCCATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTATGTTAGATGATGCTACAGTGCCCTGTTGGAACTACATAGATGACAATTTAAGAAATG
End
191334412/191365282 (Hg38)
Nearest miRNA
hsa-mir-101-1/Upstream/10926892; hsa-mir-1182/Downstream/1351046;
Junction sequence
AAAACAGTGTTCTTCAGCTATAGCACAGGGCAGATGTGCACAGACCGTCTCCCTGTAT---AGACATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTA
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Parfenov, M., et al. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A,2014,111(43): 15544-15549.