Fusion event
HPV-chr5:p15.33 integration
Detection method
WGS, RNA-seq, Whole-Exome sequencing, PCR
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Perfect
Integrated sequence
AAACTATTGCTGATCAAATATTACAATATGGAAGTATGGGTGTATTTTTTGGTGGGTTAGGAATTGGAACAGGGTCGGGTACAGGCGGACGCACTGGGTA| |TATTCCATTGGGAACAAGGCCTCCCACAGCTACAGATACACTTGCTCCTGTAAGACCCCCTTTAACAGTAGATCCTGTGGGCCCTTCTGATCCTTCTATA
End
3878131/3878017 (Hg38)
Nearest miRNA
hsa-mir-4277/Upstream/2169149; hsa-mir-10397/Downstream/2949836;
Junction sequence
ATCCCAGTGGACAGTTTTCATATGGATGTAAGCAC---ATTCCATTAGGAACAAGGCCTCCCACAGCTACAGATACACTTGCTCCTGTAAGACCCCCTTTAACA
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Parfenov, M., et al. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A,2014,111(43): 15544-15549.