Fusion event
HPV-chrX:p11.23 integration
Detection method
WGS, RNA-seq, Whole-Exome sequencing, PCR
Disease
Head and neck squamous cell carcinoma (HNSCC)
Quality evaluation
Perfect
Integrated sequence
AAAACATACACCTCCAGCACCTAAAGAAGATCCCCTTAAAAAATACACTTTTTGGGAAGTAAATTTAAAGGAAAAGTTTTCTGCAGACCTAGATCAGTTT| |CCTTTAGGACGCAAATTTTTACTACAAGCAGGATTGAAGGCCAAACCAAAATTTACATTAGGAAAACGAAAAGCTACACCCACCACCTCATCTACCTCTA
End
48069410/48209975 (Hg38)
Nearest miRNA
hsa-mir-1587/Upstream/622470; hsa-let-7f-2/Downstream/1793173;
Junction sequence
CTAATGTAAATTTTGGTTTGGCCTTCAATCCTGCTTGTAGTAAAAATTTGCGTCCTAAAG---TCCTGCCTCAGTCCCTTGAGTAGCTGGGACCACAGGCATGT
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Parfenov, M., et al. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A,2014,111(43): 15544-15549.