Basic Information
VIS ID
TVIS20004397
Fusion event
HPV-ERC2 integration
Validated
Yes
Detection method
DIPS-PCR
Data source
Curated
Sample type
Tumor
Disease
Oropharyngeal squamous cell carcinoma (OSCC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24586376
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.1
Gene
E1
Start
1392
Integrated sequence
ATGTTACAGGTAGAAGGGCGCCATGAGACTGAAACACCATGTAGTCAGTATAGTGGTGGAAGTGGGGGTGGTTGCAGTCAGTACAGTAGTGGAAGTGGGG| |GAGAGGGTGTTAGTGAAAGACACACTATATGCCAAACACCACTTACAAATATTTTAAATGTACTAAAAACTAGTAATGCAAAGGCAGCAATGTTAGCAAA
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37.p5
Start
55545015/55510987 (Hg38)
End
55545015/55510987 (Hg38)
Orient
-
Location type
Exon18
Target gene
ERC2
Nearest miRNA
hsa-let-7g/Upstream/2664435; hsa-mir-12124/Downstream/341505;
Nearest TSS
ENST00000440867/Upstream/5726; ENST00000472243/Downstream/96923;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22671, chr3-CpG: 93/Downstream/956853
Upstream sequence
CTCACAGCGAATTTATACTTTTTGATAATCTAATGCATTAGGAATGACCAATTAGAGTGAACCAGCAGGATACTGGAGATGAGGCTAGTTGTCCAACAGA
Downstream sequence
TGATCACATTCAAAATGCCCGCATCCCAACAAAAATGGAGGATCTGTCACTTTTCTCCTCCTCTGCATTCTTCCTTTCCATCATAACCAAATCCATGAGA
Target sequence
AGCTGAATCCACAGATAAAATCCCATGGAGTTCAAATTTATCCAATGATGTTTAAGTAACATAAACAAAATGTTATCAAATAATGACATTCAGCAAAGA
Reference
Olthof, N. C., et al.Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.2014, PLoS One 9(2): e88718.
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