Basic Information
VIS ID
TVIS20004431
Fusion event
HPV-TUBD1 integration
Validated
Yes
Detection method
APOT-PCR
Data source
Curated
Sample type
Disease
Oropharyngeal squamous cell carcinoma (OSCC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
End
57947254/59869893 (Hg38)
Orient
+
Location type
Exon3
Target gene
Nearest miRNA
hsa-mir-10226/Upstream/28556; hsa-mir-1250/Downstream/173132;
Upstream sequence
TTTCTACTTATCTCCAAACCTCTGGCACTATAATCTAAAATCCGTAAGATATTACAAATAAATGTTGAGAAAATCTACTCTCATAGTATAAAAGCCTAAC
Downstream sequence
TCCTGCTTAATCACTAAAAGGATAAGCACAAACAAGAAAAAAAGGAACAGGAGAGAATATAACAGCAACAAAATTTTGGAGCTGGAGAGCAAATGGTTAC
Target sequence
TTAATTTGTGGTATAATATATGCTATTAATACCTAGTAGTGATTTCTAGTTACACATGACAGACTGAGCATATCAGTTTCCTGCCACTCTCTCTCCAGA
Reference
Olthof, N. C., et al.Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.2014, PLoS One 9(2): e88718.
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