Basic Information
VIS ID
TVIS20004433
Fusion event
HPV-BCL2 integration
Validated
Yes
Detection method
APOT-PCR
Data source
Curated
Sample type
Tumor
Disease
Oropharyngeal squamous cell carcinoma (OSCC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24586376
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.1
Host Sequence
Chromosome
chr18
Cytoband
q21.3
Reference genome
GRCh37.p5
Start
60840487/63173254 (Hg38)
End
60840487/63173254 (Hg38)
Orient
-
Location type
Intron2
Target gene
BCL2
miRNAs that regulate target gene
hsa-mir-34b-5p ; hsa-mir-21-5p ; hsa-mir-204-5p ; hsa-mir-153-3p ; hsa-let-7a-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-34b-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-34c-5p ; hsa-mir-33b-5p ; hsa-mir-192-5p ; hsa-mir-195-5p ; hsa-mir-630 ; hsa-mir-451a ; hsa-mir-365a-3p ; hsa-mir-125b-5p ; hsa-mir-449a ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-136-5p ; hsa-mir-7-5p ; hsa-mir-148a-3p ; hsa-mir-24-2-5p ; hsa-mir-182-5p ; hsa-mir-196b-5p ; hsa-mir-143-3p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-103a-3p ; hsa-mir-96-5p ; hsa-mir-205-5p ; hsa-mir-126-3p ; hsa-mir-18a-5p ; hsa-mir-497-5p ; hsa-mir-1915-3p ; hsa-mir-206 ; hsa-mir-34a-3p ; hsa-mir-448 ; hsa-mir-125a-5p ; hsa-mir-708-5p ; hsa-mir-184 ; hsa-mir-30b-5p ; hsa-mir-135a-5p ; hsa-mir-224-5p ; hsa-mir-503-5p ; hsa-mir-494-3p ; hsa-mir-211-5p ; hsa-mir-9-5p ; hsa-mir-139-5p ; hsa-mir-26a-1-3p ; hsa-mir-1284 ; hsa-mir-376c-3p ; hsa-mir-190b ; hsa-mir-15a-3p ; hsa-mir-16-1-3p ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-1-2/Upstream/4722096; hsa-mir-5011/Downstream/3908330;
Nearest TSS
ENST00000575820/Upstream/11385; ENST00000634673/Downstream/34368;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/456116, chr18-CpG: 236/Downstream/145016
Nearest cancer related gene
BCL2(OG, No orient, 0)
Upstream sequence
AACCACAAAAAGTTTAGCTCCAATATAGAAGTTGTGATCAATTCTCCTTTTTGTTTTATTCCAGAAAGAAACTGGCACATAATCGTAATTAAAAACTGAA
Downstream sequence
CCAGAAAGAAACTGGCACATGTAAGATGAAGAAAAATTCTGTTTCCAACATATATTTTGCTAGGCTCACCGTTAAAATACACACAAGCCAAAAACACCGA
Target sequence
AAAAGACATCATATTGTTTAACTTGAAATAACCTTTCACAACCACAAGAAGTTTAGCTCCAATATAGAAGTTGTGATCAATTCTCCTTTTTGTTTTATT
Reference
Olthof, N. C., et al.Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.2014, PLoS One 9(2): e88718.
Curate