hsa-mir-19a-3p _CESC.png
CASZ1 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004478
Fusion event
HPV-CASZ1 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
4338
Integrated sequence
TAATTTTTTTTTTTGTTTGTT TGTTTGTTTTTTAATAAACTGTTATTACTTAACAATGCGACACAAACGTTCTGCAAAACGCACAAAACGT GCATCGG| |CTACCCAACTTTATAAAACATGCAAACAGGCAGGTACATGTCCACCTGACATTATACCTAAGG TTGAAGGCAAAACTATTGCTGAACAAATATTACAAT
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
10707431/10647374 (Hg38)
End
10707431/10647374 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
CASZ1
miRNAs that regulate target gene
hsa-mir-151a-5p ; hsa-mir-4665-3p ; hsa-mir-486-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-885-3p ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-3195 ; hsa-mir-3648 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-1908-3p ; hsa-mir-6784-5p ; hsa-mir-7975 ; hsa-mir-4540 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4670-3p ; hsa-mir-648 ; hsa-mir-6838-3p ; hsa-mir-4517 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-8068 ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-12136/Upstream/679916; hsa-mir-101-1/Downstream/1381784;
Nearest TSS
ENST00000473358/Upstream/2298; ENST00000613864/Downstream/3726;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/7333, chr1-CpG: 25/Downstream/379
Upstream sequence
CAGGTATATCAGTGACTCAAAGCTTCAAAGTGACAGCTTATAAAGGGATACAAGGAATCTTGCATTGCAAAGAAAAAGAAAAAGATCTAGAAGCTGTGCC
Downstream sequence
ACACGTTTTTTCTCCTAAGGAAAAAAAAAATCTCGAGAAAGAAGAAAAGCTTTGCCATTCACATCAGTTTACTCTGAAACTAGTTTTAGGAGCTTATTTC
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate