Basic Information
VIS ID
TVIS20004481
Fusion event
HPV-chr2:p22.3 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
2823
Integrated sequence
ACTGGAAATCCTTTTTCTCAAGGACGTGGTCCAGATTAAGTTTGC ACGAGGACGAGGACAAGGAAAACGATGGAGACTCTTTGCCAACGTTTAAATGTG| |TGTCAGGACAAAATAC TAACACATTATGAAAATGATAGTACAGACCTACGTGACCATATAGACTATTGGAAACACATGCGCCTAGA ATGTGCTATTTA
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
34896821/34671754 (Hg38)
End
34896821/34671754 (Hg38)
Nearest miRNA
hsa-mir-1301/Upstream/1253190; hsa-mir-10b/Downstream/799651;
Nearest TSS
ENST00000437798/Upstream/287966; ENST00000607437/Downstream/5801;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/944137, chr2-CpG: 191/Downstream/1683500
Nearby gene
LINC01320(+5803) ;
Upstream sequence
ggggggggggggggggggggggggggggggggggggggggggggggggggggggagggaggggggggtgagagggggggggggggggggggggggggggg
Downstream sequence
cgggaaggatgggtacaaataagctcagactgagaagaatgcaataaatacccaaactttcaatgcccacacatcaacgaacatccgtaagatcatccag
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate