Basic Information
VIS ID
TVIS20004482
Fusion event
HPV-chr2:q22.3 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
3596
Integrated sequence
GAAGAAACACAGACGACTATCCAGCGACCAAGATCAGAGCCAGACACCGGAAA CCCCTGCCACACCACTAAGTTGTTGCACAGAGACTCAGTGGACAGT| |GCTCCAATCCTCACTGCATTTAAC AGCTCACACAAAGGACGGATTAACTGTAATAGTAACACTACACCCATAGTACATTTAAAAGGTGATGCTA ATAC
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
146512049/145754481 (Hg38)
End
146512049/145754481 (Hg38)
Fragile sites / regions
FRA2S ; FRA2K
Nearest miRNA
hsa-mir-128-1/Upstream/5167796; hsa-mir-10b/Downstream/3575797;
Nearest TSS
ENST00000437798/Upstream/151058; ENST00000414967/Downstream/160609;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1229993, chr2-CpG: 49/Downstream/832752
Upstream sequence
gggggggggggggggggggggggggggggggggggggggggggggggggggagggaggggggggtgagaggggggggggggggggggggggggggggggg
Downstream sequence
TTAACTATAGAGTTCGGTTAAAGTGGGTAATGGAAAACACAGCACTATGTTTCCATTTGTTTCTGATTTACTACTTCCAGCTCTACATTTATTCCTCTTA
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate