hsa-mir-4738-3p _CESC.png
MBD5 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004483
Fusion event
HPV-MBD5 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
2774
Integrated sequence
TTCCATTTGACGAAAACGGAAAT CCAGTGTATGAGCTTAATGATAAGAACTGGAAATCCTTTTTCTCAAGGACGTGGTCCAGATTAAGTTTGC ACGAG| |GACGAGGACAAGGAAAACGATGGAGACTCTTTGCCAACGTTTAAATGTGTGTCAGGACAAAATAC TAACACATTATGAAAATGATAGTACAGACCTACG
Host Sequence
Chromosome
chr2
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
149157969/148400400 (Hg38)
End
149157969/148400400 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2K
Target gene
MBD5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7151-5p ; hsa-mir-6796-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-3201 ; hsa-mir-429 ; hsa-mir-4314 ; hsa-mir-4502 ; hsa-mir-4738-3p ; hsa-mir-4790-3p ; hsa-mir-4791 ; hsa-mir-6776-5p ; hsa-mir-6861-5p ; hsa-mir-8084
Nearest miRNA
hsa-mir-128-1/Upstream/7813715; hsa-mir-10b/Downstream/929878;
Nearest TSS
ENST00000437798/Upstream/69894; ENST00000637159/Downstream/47167;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/379439, chr2-CpG: 193/Downstream/243702
Upstream sequence
gggggggggggggggggggggggggggggggggggggggggggagggaggggggggtgagaggggggggggggggggggggggggggggggggggggggg
Downstream sequence
CAACTCTAACTCTATTGCCATCCTGGCCCTGGGCTGAAACCCTTATTCACTGACATAATCAGAAACTGGTTATAATGAGATCCTAGCTCCCATTCCACCT
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate