hsa-mir-362-3p _CESC.png
hsa-mir-6720-5p _CESC.png
PARD3B _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004485
Fusion event
HPV-PARD3B integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
2412
Integrated sequence
TATTACTATATGGTGCAGCTAACACAGGTA AATCATTATTTGGTATGAGTTTAATGAAATTTCTGCAAGGGTCTGTAATATGTTTTGTAAATTCTAAAA| |G CCATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTATGTTAGATGATGCTACAGTGCCCTGTTGG AACTACATAGATGACAATTTAAGAAAT
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
206103492/205238768 (Hg38)
End
206103492/205238768 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
PARD3B
miRNAs that regulate target gene
hsa-mir-6873-3p ; hsa-mir-3941 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6758-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3180-5p ; hsa-mir-4642 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-4267
Nearest miRNA
hsa-mir-10b/Upstream/16105657; hsa-mir-1244-1/Downstream/1544466;
Nearest TSS
ENST00000437798/Upstream/135076; ENST00000465890/Downstream/54724;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/692581, chr2-CpG: 91/Downstream/443111
Upstream sequence
gggggggggggggggggggggggagggaggggggggtgagagggggggggggggggggggggggggggggggggggggggggggggggggaggggggggg
Downstream sequence
ttgcagtgagccaagatcgcaccattgcactacagcctgggcaacaaaagctaaaaaactccgtttcaaaaaaaaaaaaaaatatatatatatatatata
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate