hsa-mir-372-3p _CESC.png
hsa-mir-19a-3p _CESC.png
hsa-mir-146b-5p _CESC.png
ERBB4 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004486
Fusion event
HPV-ERBB4 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
3489
Integrated sequence
ACATCTGTGTTTAGCAGC AACGAAGTATCCTCTCCTGAAATTATTAGGCAGCACTTGGCCAACCACCCCGCCGCGACCCATACCAAAG CCGTCGCCTT| |GGGCACCGAAGAAACACAGACGACTATCCAGCGACCAAGATCAGAGCCAGACACCGGAAA CCCCTGCCACACCACTAAGTTGTTGCACAGAGACTCAGT
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
212251450/211386725 (Hg38)
End
212251450/211386725 (Hg38)
Location type
Intronic
Target gene
ERBB4
miRNAs that regulate target gene
hsa-mir-372-3p ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-146a-5p ; hsa-mir-145-5p ; hsa-mir-221-3p ; hsa-mir-302b-3p ; hsa-mir-193a-3p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-10b/Upstream/3631844; hsa-mir-1244-1/Downstream/1039538;
Nearest TSS
ENST00000437798/Upstream/715110; ENST00000434559/Downstream/278629;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/909913, chr2-CpG: 86/Downstream/1150731
Nearest cancer related gene
ERBB4(TSG, No orient, 0)
Upstream sequence
gggggggggggggggggggggggggggggggggggggggggggagggggggggggggggggggggggggggggggggggggggagggggggggggggggg
Downstream sequence
GCCTAGGCCTTTACTGGATCACAAATGTTGTGCTGGTCAGCTATCTGGCAATTTCTATTCTGTACTTTGTTTATCTTGATGGAAGTGAACTTCGAATGGC
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate