hsa-mir-331-3p _CESC.png
FHIT _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004489
Fusion event
HPV-FHIT integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
2868
Integrated sequence
ACGAGGACGAGGACAAGGAAAACGATGGAGACTCTTTGCCAACGTTTAAATGTGTGTCAGGACAAAATAC TAACACATTATGAAAATGATAGTACAGA| |CCTACGTGACCATATAGACTATTGGAAACACATGCGCCTAGA ATGTGCTATTTATTACAAGGCCAGAGAAATGGGATTTAAACATATTAACCACCAAGT
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
60486966/60501233 (Hg38)
End
60486966/60501233 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/4648639; hsa-mir-12124/Downstream/116572;
Nearest TSS
ENST00000440867/Upstream/420393; ENST00000475527/Downstream/750151;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1451015, chr3-CpG: 48/Downstream/749699
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
CCATTTTTTAATTTACTTGTTTTGGATGGCTTGTCTATACTCCTTCCCTTAAGGGGTATCATGTATGGTGATAGGTATCTAGAGCTTAATGCTACATGTG
Downstream sequence
AGCCAGATTTCAATATACGTTTAATGTTTTTTGATAACTCGTTGTAGGTAGCCACTATTTATCTTATTTGAGTTACAAAGATACATAAACACAAAATTTA
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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