hsa-mir-21-5p _CESC.png
ATP11B _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004492
Fusion event
HPV-ATP11B integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
1642
Integrated sequence
CAGAATTAGTAAGACCATT TAAAAGTAATAAATCAACGTGTTGCGATTGGTGTATTGCTGCATTTGGACTTACACCCAGTATAGCTGAC AGTATAAAA| |ACACTATTACAACAATATTGTTTATATTTACACATTCAAAGTTTAGCATGTTCATGGGGAA TGGTTGTGTTACTATTAGTAAGATATAAATGTGGAAAA
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37/hg19
Start
182088476/182370688 (Hg38)
End
182088476/182370688 (Hg38)
Location type
Intronic
Target gene
ATP11B
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-652-3p ; hsa-mir-222-3p
Nearest miRNA
hsa-let-7g/Upstream/5855537; hsa-mir-1224/Downstream/1516112;
Nearest TSS
ENST00000440867/Upstream/5541; ENST00000492416/Downstream/115676;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/643476, chr3-CpG: 70/Downstream/311602
Upstream sequence
AGTTCAGTCACTATTATCTCTGATCTGTGGAGTGGTCAACAATGTTTTATCAAGGAAAACTACTATAACCAGCATGGAAACAAGGGAAAGTGTCTGTTGA
Downstream sequence
acctaatttaaaaaaaaaaaaaatttgtagagacagggtctcactacattgcccaggatggtctcaaacttctggactcaagtgatcctcctgcctcagc
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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