Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004495
Fusion event
HPV-MRPL1 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Gene
E2
Start
2615
Integrated sequence
TTGGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGAC CATTGGTACAACTAAAATGCCCTCCATTATTAATTACATCTAACATTAATGCTGGTACA| |GATTCTAGGTG GCCTTATTTACATAATAGATTGGTGGTGTTTACATTTCCTAATGAGTTTCCATTTGACGAAAACGGAAAT CCAGTGTATGAGCTTAA
Host Sequence
Chromosome
chr4
Cytoband
q21.1
Reference genome
Start
End
78848346/77927192 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-12113/Upstream/1351566; hsa-mir-1243/Downstream/4826145;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/64331, chr4-CpG: 75/Downstream/130019
Upstream sequence
tggtgagtcccaccatcagccattcaactgaacttaattattcagttccagtacatatgtctagtatgtactgaattgttCAGAATTGTTCATCTGTGTC
Downstream sequence
GCAACCTAATTAATTTTAGTTACAGAGTGTCTAATAAAAAATATTGCCTGGTAGATGTTGCCTGAATTAATGCTATATAATTAACAAATTGTTGTTTTAA
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.