Basic Information
VIS ID
TVIS20004497
Fusion event
HPV-DUX4L2 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
1030
Integrated sequence
GTTTTATGTAGAGGCTGTAGTGGAAAAAAAAACAGGGGATGCTATATCAGATGACGAGAACGA AAATGACAGTGATACAGGTGAAGATTTGGTAGATTT| |TATAGTAAATGATAATGATTATTTAACACAGGCA GAAACAGAGACAGCACATGCGTTGTTTACTGCACAGGAAGCAAAACAACATAGAGATGCAGTACA
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
191040400/190119245 (Hg38)
End
191040400/190119245 (Hg38)
Location type
Intronic
Target gene
DUX4L2
Nearest miRNA
hsa-mir-12113/Upstream/5180805;
Nearest TSS
ENST00000502981/Upstream/54743; ENST00000616166/Downstream/54529;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/26791, chr4-CpG: 24/Downstream/53888
Upstream sequence
ctgcattccagactatgcaacagaccaagatcctgtcttaaaaaaagaaaGCTACTCTTTCAGGTTCATAATCAACTCAAGGTGGTTAATGAGATTAGTA
Downstream sequence
gacaaaaacatgtttattaatgggctaaaatatctttagtttctctgtaaaaataagtagccaaaagtatgtaaacttgaattatttatcttcagtaatg
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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