Basic Information
VIS ID
TVIS20004498
Fusion event
HPV-chr5:p15.32 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
1948
Integrated sequence
TTGGTATAAAACAGGTATATCAAATATTAGTGAAGTGTATGGAGACACGCCAGAATGGATACAAAGAC AAACAGTATTACAACATAGTTTTAATGATTG| |TACATTTGAATTATCACAGATGGTACAATGGGCCTACGA TAATGACATAGTAGACGATAGTGAAATTGCATATAAATATGCACAATTGGCAGACACTAA
Host Sequence
Chromosome
chr5
Cytoband
p15.32
Reference genome
GRCh37/hg19
Start
4583408/4583295 (Hg38)
End
4583408/4583295 (Hg38)
Nearest miRNA
hsa-mir-4277/Upstream/2874427; hsa-mir-10397/Downstream/2244558;
Nearest TSS
ENST00000502646/Upstream/71033; ENST00000513925/Downstream/57436;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/620897, chr5-CpG: 39/Downstream/282909
Upstream sequence
tagcactgaatgtctacatcaagaagatacatctgaaattaacaacctaaaatcgcacctaaaaaaaaaaaaaaaacagaaaaacaagaacaaaactaaa
Downstream sequence
ACCATTAATTCAAATGTGCCGTAGGAGTTTTCGGAATATGGAGCTGGAGCTTTGAAATTGCCATTAGAATGGTCCATGTTTATTCCTGCTATGCGCGATT
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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