Basic Information
VIS ID
TVIS20004499
Fusion event
HPV-chr5:p14.1 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
3286
Integrated sequence
ATTATACA AACTGGACACATATATATATTTGTGAAGAAGCATCAGTAACTGTGGTAGAGGGTCAAGTTGACTATTATG GTTTATATTATGTTCATGAA| |GGAATACGAACATATTTTGTGCAGTTTAAAGATGATGCAGAAAAATATAG TAAAAATAAAGTATGGGAAGTTCATGCGGGTGGTCAGGTAATATTATGT
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
25574739/25574630 (Hg38)
End
25574739/25574630 (Hg38)
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/8418638; hsa-mir-103a-1/Downstream/6361472;
Nearest TSS
ENST00000502646/Upstream/128705; ENST00000514255/Downstream/825189;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/383626, chr5-CpG: 29/Downstream/334603
Upstream sequence
atatctctgttttggtaccagtaccaGTACCATCTTTATTTTTCTGATGAGCTCATATCATTTCCCAATTCCCAGCAACACACACTGTGGCCTCAGTTTT
Downstream sequence
AAAATTGAGACACTGAGGACAAGGTGTTTCTTGCTTTTAATTTATACTTTCCTCAGGATGCTATACTTATGGAGATAAATTGGCTGGAAAGGAAATTAAC
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate