Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004502
Fusion event
HPV-CENPW integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Gene
E2
Start
2143
Integrated sequence
ACTAATAGTAATGCA AGTGCCTTTCTAAAAAGTAATTCACAGGCAAAAATTGTAAAGGATTGTGCAACAATGTGTAGACATTATA AACGAGCAGAAAA| |AAAACAAATGAGTATGAGTCAATGGATAAAATATAGATGTGATAGGGTAGATGATGG AGGTGATTGGAAGCAAATTGTTATGTTTTTAAGGTATCAAGG
Host Sequence
Chromosome
chr6
Cytoband
q22.32
Reference genome
End
126782491/126461345 (Hg38)
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-10398/Upstream/6446088; hsa-mir-1202/Downstream/23286;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/121104, chr6-CpG: 30/Downstream/182158
Nearest cancer related gene
CENPW(OG, No orient, 0)
Upstream sequence
tcacacTTCTATACATAAAATTAGAGAGCAGCCAGCACACATAATTCTGGACCATGGAGAtatctagcagagttgacacttggaccagatcttttattga
Downstream sequence
ctctcagggatgtccttattagcagcatgcaaatggactaatacaTGTCCCAAATACTAAGTTATTTCAAAGAAAATGTGCTAGCCTTGGAGTCTTACTG
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.