Basic Information
VIS ID
TVIS20004504
Fusion event
HPV-chr7:q11.21 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
1813
Integrated sequence
TACTATTAGTAAGATATAAATGTGGAAAAAATAGAGAAACAATTGAAAAATTGCTGTCTAA ACTATTATGTGTGTCTCCAATGTGTATGATGATAGAGC| |CTCCAAAATTGCGTAGTACAGCAGCAGCATTA TATTGGTATAAAACAGGTATATCAAATATTAGTGAAGTGTATGGAGACACGCCAGAATGGATACAAA
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
61969363/62508985 (Hg38)
End
61969363/62508985 (Hg38)
Fragile sites / regions
FRA7J
Nearest miRNA
hsa-mir-1183/Upstream/5103895; hsa-mir-10399/Downstream/1112105;
Nearest TSS
ENST00000635602/Upstream/5058808; ENST00000418297/Downstream/545446;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/128088, chr7-CpG: 49/Downstream/545152
Upstream sequence
ttaagcccagaagttcgagacttcgaggctgcagtgggtagcagaatgagactctgcctcaaataaTGATAATAATTTACAGGACTTAAACCTCTGTCTC
Downstream sequence
aagaagagttctcaggaacttttttgtgttgtgtgtattcaactcacagagttgaaccttgctttagagagagcagatttgaaacactcttgctgtggca
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate