Basic Information
VIS ID
TVIS20004505
Fusion event
HPV-chr8:q23.2 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
2627
Integrated sequence
TTAGTTTCTATGGATGTAAAGCATAGAC CATTGGTACAACTAAAATGCCCTCCATTATTAATTACATCTAACATTAATGCTGGTACAGATTCTAGGTG | |GCCTTATTTACATAATAGATTGGTGGTGTTTACATTTCCTAATGAGTTTCCATTTGACGAAAACGGAAAT CCAGTGTATGAGCTTAATGATAAGAACTG
Host Sequence
Chromosome
chr8
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
111272354/110260125 (Hg38)
End
111272354/110260125 (Hg38)
Nearest miRNA
hsa-mir-12123/Upstream/5775660; hsa-mir-10400/Downstream/2383368;
Nearest TSS
ENST00000518652/Upstream/284278; ENST00000523264/Downstream/89482;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/284282, chr8-CpG: 21/Downstream/3172472
Upstream sequence
tgccccatgatcagttgcctccccccaggttcctcccacaacatgtgggaattcaagatgagatttgggcagggacacagccaaaccatatcaGTCATGT
Downstream sequence
attcttatacaccaataacagacaaacagagagccaaatcatgagtgaactcccattcacaatggttccaaagagagtaaaatacctaggaatccaactt
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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