IFT74 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004511
Fusion event
HPV-IFT74 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
2590
Integrated sequence
CATAGATGACAATTTAAGAAATGCATTGGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGAC CATTGGTACAACTAAAATGCCCTCCATTATTAAT| |TACATCTAACATTAATGCTGGTACAGATTCTAGGTG GCCTTATTTACATAATAGATTGGTGGTGTTTACATTTCCTAATGAGTTTCCATTTGACGAAAA
Host Sequence
Chromosome
chr9
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
26947928/26947930 (Hg38)
End
26947928/26947930 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
IFT74
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-101-2/Upstream/5435745; hsa-let-7a-1/Downstream/1915696;
Nearest TSS
ENST00000422679/Upstream/467; ENST00000518614/Downstream/8365;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/350, chr9-CpG: 37/Downstream/8373
Upstream sequence
actagtaatatattctcagtgtctccttttccccctacaccatttcattgctttgcatatgtaatctagctttttctttcactcattctctcataaatca
Downstream sequence
CCATTCTGGGACCAGGGTGGGGAGGATGGGTACCTGAAGCTGGAGGGGGCCAGCCCAGGGAGGTGTGAGTTTGTTCTGAAAACCACCCTCACTTCAGCTt
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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