UBAP2 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004512
Fusion event
HPV-UBAP2 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
1228
Integrated sequence
CAGGTTC TAAAACGAAAGTATTTGGTAGTCCACTTAGTGATATTAGTGGATGTGTAGACAATAATATTAGTCCTAGA TTAAAAGCTATATGTATAGAA| |AAACAAAGTAGAGCTGCAAAAAGGAGATTATTTGAAAGCGAAGACAGCG GGTATGGCAATACTGAAGTGGAAACTCAGCAGATGTTACAGGTAGAAGGG
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33980798/33980800 (Hg38)
End
33980798/33980800 (Hg38)
Location type
Intronic
Target gene
UBAP2
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-34a-5p ; hsa-mir-320a ; hsa-let-7f-5p ; hsa-let-7a-5p ; hsa-mir-218-5p ; hsa-mir-335-3p ; hsa-mir-6801-5p
Nearest miRNA
hsa-mir-101-2/Upstream/512865; hsa-let-7a-1/Downstream/1627294;
Nearest TSS
ENST00000422679/Upstream/31834; ENST00000448245/Downstream/8243;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/162498, chr9-CpG: 75/Downstream/67841
Upstream sequence
attcccaagagcagtgtatgaggtttccagtttttctacatcatctccaacacttgttatttttcacatttttaattttaccttttctagtagatgtgaa
Downstream sequence
tggcaatctgagccacagccactccaggaatgtgtaacagtcaggaagaagaggaggcaaaggagactgagacagcacagtcagagagacagggagacag
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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