DENND1A _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004513
Fusion event
HPV-DENND1A integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
1226
Integrated sequence
TACAGGTTC TAAAACGAAAGTATTTGGTAGTCCACTTAGTGATATTAGTGGATGTGTAGACAATAATATTAGTCCTAGA TTAAAAGCTATATGTATAG| |AAAAACAAAGTAGAGCTGCAAAAAGGAGATTATTTGAAAGCGAAGACAGCG GGTATGGCAATACTGAAGTGGAAACTCAGCAGATGTTACAGGTAGAAG
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
126291635/123529356 (Hg38)
End
126291635/123529356 (Hg38)
Location type
Intronic
Target gene
DENND1A
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-let-7a-1/Upstream/43734; hsa-mir-12126/Downstream/1163086;
Nearest TSS
ENST00000422679/Upstream/37472; ENST00000423942/Downstream/53861;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/137073, chr9-CpG: 109/Downstream/470091
Upstream sequence
cttttttcactccacatatgtttgcaagactcccccatgttgttagacataaatgcactttgttcttgctcattgctggttgatatcccattgtatggat
Downstream sequence
AAGGGTGAGAGGTGGGAGTTAGCAGCCTCTGAACATCTGTGTACCATGGGACCCCCTTTCCTCCTGCATGGTACCCCAGACAAGGAGCCTAGTAAGAGAT
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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