LOXL4 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004515
Fusion event
HPV-LOXL4 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
2344
Integrated sequence
GTAGAGTTTATGTCATTTTTAACTGCA TTAAAAAGATTTTTGCAAGGCATACCTAAAAAAAATTGCATATTACTATATGGTGCAGCTAACACAGGTA A| |ATCATTATTTGGTATGAGTTTAATGAAATTTCTGCAAGGGTCTGTAATATGTTTTGTAAATTCTAAAAG CCATTTTTGGTTACAACCATTAGCAGATGC
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
100058840/98299083 (Hg38)
End
100058840/98299083 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LOXL4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-29b-3p
Nearest miRNA
hsa-mir-107/Upstream/423186; hsa-mir-1287/Downstream/96135;
Nearest TSS
ENST00000439456/Upstream/30833; ENST00000488090/Downstream/89353;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/30332, chr10-CpG: 52/Downstream/147466
Upstream sequence
GCAAGAAATGAAGAACTAAATCTTTGCCTCACACATGgaaagaaaagaaaaaagaaaaagagagagagaaagaaggaaagaaagaaaagaaagaaagaaa
Downstream sequence
gaagaaagaaagaaagaagaaagaaagaaagaaagaaagagaaagaaagaagaaagTCAACGTGTTTctgaagagaaggccaacccacatcccctccaaa
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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