hsa-mir-4679 _CESC.png
BCL2L14 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004518
Fusion event
HPV-BCL2L14 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E5
Start
1794
Integrated sequence
CATGGGGAA TGGTTGTGTTACTATTAGTAAGATATAAATGTGGAAAAAATAGAGAAACAATTGAAAAATTGCTGTCTAA ACTATTATGTGTGTCTCCA| |ATGTGTATGATGATAGAGCCTCCAAAATTGCGTAGTACAGCAGCAGCATTA TATTGGTATAAAACAGGTATATCAAATATTAGTGAAGTGTATGGAGAC
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12233422/12080488 (Hg38)
End
12233422/12080488 (Hg38)
Location type
Intronic
Target gene
BCL2L14
miRNAs that regulate target gene
hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-6503-5p ; hsa-mir-4527 ; hsa-mir-8069 ; hsa-mir-570-3p ; hsa-mir-4635 ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-3663-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2840937; hsa-let-7i/Downstream/31464;
Nearest TSS
ENST00000382841/Upstream/1189; ENST00000543990/Downstream/51342;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/430869, chr12-CpG: 102/Downstream/186257
Upstream sequence
tcatactgttttccataatggctgtaccaatttacattcccaccaacagtgtataagaattcctctttcttccaattcttaccaacattggtcatttatt
Downstream sequence
TATTATTGCTTTAATAGAATGATCAATGCACTTAGATTGTGTAGTGTGAGAGAGCTTGGCCTTACATAGTCACAGTATGAAGAGACCGaatttttttttt
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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