hsa-mir-21-5p _CESC.png
KLF5 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004520
Fusion event
HPV-KLF5 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
2146
Integrated sequence
AATAGTAATGCA AGTGCCTTTCTAAAAAGTAATTCACAGGCAAAAATTGTAAAGGATTGTGCAACAATGTGTAGACATTATA AACGAGCAGAAAAAAA| |ACAAATGAGTATGAGTCAATGGATAAAATATAGATGTGATAGGGTAGATGATGG AGGTGATTGGAAGCAAATTGTTATGTTTTTAAGGTATCAAGGTGT
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
73999476/73425339 (Hg38)
End
73999476/73425339 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
KLF5
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-141-3p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-143-3p ; hsa-mir-4480 ; hsa-mir-489-3p ; hsa-mir-4668-3p ; hsa-mir-153-3p
Nearest miRNA
hsa-mir-1297/Upstream/7207015; hsa-mir-1267/Downstream/4272673;
Nearest TSS
ENST00000623511/Upstream/350324; ENST00000430033/Downstream/121502;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/365107, chr13-CpG: 31/Downstream/708633
Nearest cancer related gene
KLF5(TSG, No orient, 0)
Upstream sequence
GATTTTATCTGATCTTTGTTGGTTTCTATCAATTGTGGCACTGGAGCCTGTTAAAAATAAATACCATATAGAGACACGTTTTCCGAAAGCAAAACCTGGT
Downstream sequence
GTCTGCAAAACTTACAGGCTCATGGGTTTCTAATTGGGAGTGTGCACACAGACCCCTCCAAGGTAAATACATACATTCTAAATTTACCCGAGCGCTTTAA
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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