Basic Information
VIS ID
TVIS20004538
Fusion event
HPV-URI1 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
3897
Integrated sequence
GCAATTGTTACACTTACATATGATAGTGAATGGCAA CGTGACCAATTTTTGTCTCAAGTTAAAATACCAAAAACTATTACAGTGTCTACTGGATTTATG| |TCTATAT GACAAATCTTGATACTGCATCCACAACATTACTGGCGTGCTTTTTGCTTTGCTTTGTGTGCTTTTGTGTG TCTGCCTATTAATACGTCCGC
Host Sequence
Chromosome
chr19
Cytoband
q11
Reference genome
GRCh37/hg19
Start
30498221/30007314 (Hg38)
End
30498221/30007314 (Hg38)
Location type
Intronic
Target gene
URI1
miRNAs that regulate target gene
hsa-mir-598-3p ; hsa-mir-376a-5p
Nearest miRNA
hsa-mir-10395/Upstream/9607960; hsa-let-7e/Downstream/5115386;
Nearest TSS
ENST00000633603/Upstream/3019; ENST00000575242/Downstream/1766;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/64356, chr19-CpG: 51/Downstream/215187
Nearest cancer related gene
URI1(OG, No orient, 0)
Upstream sequence
aatcaatcccagcattgtttccaatgagcagcactcagagtccttGCTCCCCGCTGAAGATCTGTATCTAGAGAGGAGCATGCCATGGTCCCTGGCAACA
Downstream sequence
AGAGACATTCATCCTTGGAGTTCTGTTTGGCTTAAAAATTGTGACCCCTCTGTTTCAATATTTCCCTTGCCCCAAAAGAAAGTCTCATTAAGTCTGGGTT
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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