Basic Information
VIS ID
TVIS20004539
Fusion event
HPV-chr20:p12.2 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E5
Start
2470
Integrated sequence
AATTTCTGCAAGGGTCTGTAATATGTTTTGTAAATTCTAAAAG CCATTTTTGGTTACAACCATTAGCAGATGCCAAAATAGGTATGTTAGATGATGCTA| |CAGTGCCCTGTTGG AACTACATAGATGACAATTTAAGAAATGCATTGGATGGAAATTTAGTTTCTATGGATGTAAAGCATAGAC CATTGGTACAACTA
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
11159613/11178965 (Hg38)
End
11159613/11178965 (Hg38)
Fragile sites / regions
FRA20B
Nearest miRNA
hsa-mir-103a-2/Upstream/529270; hsa-mir-1-1/Downstream/7291650;
Nearest TSS
ENST00000382410/Upstream/151205; ENST00000450368/Downstream/89870;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/504002, chr20-CpG: 37/Downstream/507909
Nearby gene
LOC105372528(-512) ;
Upstream sequence
AGCATATATTACCTGCATAAAAATATATATATATTAGGAGTGTCAtgagctgagatggcaccactgcactctagcctgggcgacagagagactccatctc
Downstream sequence
AGTTCCTATAATAAAAATGAAACAATAAATGCATAGAAATATGAGGAAGAAATTACACCCATTAAATGCACCTAGCCTGATGAGTGATAGGATGGCTGCT
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
Curate